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Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization

Abstract:

All orthobunyaviruses possess three genome segments of single-stranded negative sense RNA that are encapsidated with the virus-encoded nucleocapsid (N) protein to form a ribonucleoprotein (RNP) complex, which is uncharacterized at high resolution. We report the crystal structure of both the Bunyamwera virus (BUNV) N–RNA complex and the unbound Schmallenberg virus (SBV) N protein, at resolutions of 3.20 and 2.75 Å, respectively. Both N proteins crystallized as ring-like tetramers and exhibit a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/nar/gkt268

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Department:
Oxford, MSD, Pathology Dunn School
Tanner, SJ More by this author
Walter, CT More by this author
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
41
Issue:
11
Pages:
5912-5926
Publication date:
2013-06-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:659851
URN:
uri:68f1f25d-104b-4891-8efc-6581ce594fa0
UUID:
uuid:68f1f25d-104b-4891-8efc-6581ce594fa0
Local pid:
pubs:659851
Language:
English
Keywords:

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