Journal article
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
- Abstract:
-
How different extracellular stimuli can evoke different spatiotemporal Ca2+ signals is uncertain. We have elucidated a novel paradigm whereby different agonists use different Ca2+-storing organelles ("organelle selection") to evoke unique responses. Some agonists select the endoplasmic reticulum (ER), and others select lysosome-related (acidic) organelles, evoking spatial Ca2+ responses that mirror the organellar distribution. In pancreatic acinar cells, acetylcholine and bombesin exclusively...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m311088200
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Authors
Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 279
- Issue:
- 8
- Pages:
- 7234-7240
- Publication date:
- 2004-02-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
106195
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:106195
- UUID:
-
uuid:68ee80cf-ffac-48d8-8790-00a6d4795a70
- Local pid:
- pubs:106195
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2004
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