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Journal article

Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.

Abstract:

How different extracellular stimuli can evoke different spatiotemporal Ca2+ signals is uncertain. We have elucidated a novel paradigm whereby different agonists use different Ca2+-storing organelles ("organelle selection") to evoke unique responses. Some agonists select the endoplasmic reticulum (ER), and others select lysosome-related (acidic) organelles, evoking spatial Ca2+ responses that mirror the organellar distribution. In pancreatic acinar cells, acetylcholine and bombesin exclusively...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m311088200

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Journal:
Journal of biological chemistry
Volume:
279
Issue:
8
Pages:
7234-7240
Publication date:
2004-02-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
106195
Language:
English
Keywords:
Pubs id:
pubs:106195
UUID:
uuid:68ee80cf-ffac-48d8-8790-00a6d4795a70
Local pid:
pubs:106195
Deposit date:
2012-12-19

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