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Journal article

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neo-antigen burden and immune response

Abstract:

Genomic instability, a hallmark of cancer, is generally thought to occur in the mid to late stages of tumorigenesis, following the acquisition of permissive molecular aberrations such as TP53 mutation or whole genome doubling. Tumours with somatic POLE exonuclease domain mutations are notable for their extreme genomic instability (their mutation burden is among the highest in human cancer), distinct mutational signature, lymphocytic infiltrate and excellent prognosis. To what extent these cha...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/path.5081

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More from this funder
Name:
Health Foundation/Academy of Medical Sciences Clinician Scientist Fellowship
Funding agency for:
Church, DN
Grant:
AMS-CSF4-Church
More from this funder
Name:
Engineering and Physical Sciences Research Council
Funding agency for:
Temko, D
Grant:
CoMPLEX
More from this funder
Name:
Research Fund Flanders
Grant:
G.0827.13
Funding agency for:
Amant, F
More from this funder
Name:
Cancer Research UK
Funding agency for:
Graham, TA
Grant:
202778/Z/16/Z
C399/A2291
More from this funder
Name:
Wellcome Trust
Grant:
090532/Z/09/Z
202778/Z/16/Z
Funding agency for:
Graham, TA
Glaire, M
Publisher:
Wiley
Journal:
Journal of Pathology More from this journal
Volume:
245
Issue:
3
Pages:
283-296
Publication date:
2018-03-31
Acceptance date:
2018-03-20
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Keywords:
Pubs id:
pubs:830464
UUID:
uuid:68e8ce0d-c9c0-4f10-9886-821a240997d2
Local pid:
pubs:830464
Deposit date:
2018-03-20

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