Journal article icon

Journal article

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neo-antigen burden and immune response

Abstract:

Genomic instability, a hallmark of cancer, is generally thought to occur in the mid to late stages of tumorigenesis, following the acquisition of permissive molecular aberrations such as TP53 mutation or whole genome doubling. Tumours with somatic POLE exonuclease domain mutations are notable for their extreme genomic instability (their mutation burden is among the highest in human cancer), distinct mutational signature, lymphocytic infiltrate and excellent prognosis. To what extent these cha...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1002/path.5081

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Glaire, M
More from this funder
Funding agency for:
Bosse, T
More from this funder
Funding agency for:
Graham, TA
Expand funders...
Publisher:
Wiley Publisher's website
Journal:
Journal of Pathology Journal website
Volume:
245
Issue:
3
Pages:
283-296
Publication date:
2018-03-31
Acceptance date:
2018-03-20
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Pubs id:
pubs:830464
URN:
uri:68e8ce0d-c9c0-4f10-9886-821a240997d2
UUID:
uuid:68e8ce0d-c9c0-4f10-9886-821a240997d2
Local pid:
pubs:830464

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP