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Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes

Abstract:

In the heart compartmentalisation of cAMP/protein kinase A (PKA) signalling is necessary to achieve a specific functional outcome in response to different hormonal stimuli. Chronic exposure to catecholamines is known to be detrimental to the heart and disrupted compartmentalisation of cAMP signalling has been associated to heart disease. However, in most cases it remains unclear whether altered local cAMP signalling is an adaptive response, a consequence of the disease or whether it contribut...

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Publication status:
In press
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cellsig.2015.10.003

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Grant:
PG/10/75/28537
PG/15/5/31110
RG/12/3/29423
Publisher:
Elsevier Publisher's website
Journal:
Cellular Signalling Journal website
Publication date:
2015-10-01
DOI:
ISSN:
0898-6568
Source identifiers:
574959
Keywords:
Pubs id:
pubs:574959
UUID:
uuid:68e5fbbc-14a2-4df2-91e1-04f5d5a2270e
Local pid:
pubs:574959
Deposit date:
2015-11-24

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