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Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes

Abstract:

In the heart compartmentalisation of cAMP/protein kinase A (PKA) signalling is necessary to achieve a specific functional outcome in response to different hormonal stimuli. Chronic exposure to catecholamines is known to be detrimental to the heart and disrupted compartmentalisation of cAMP signalling has been associated to heart disease. However, in most cases it remains unclear whether altered local cAMP signalling is an adaptive response, a consequence of the disease or whether it contribut...

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Publication status:
In press
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.cellsig.2015.10.003

Authors


Fields, LA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Grant:
PG/10/75/28537; RG/12/3/29423; PG/15/5/31110
Publisher:
Elsevier Publisher's website
Journal:
Cellular Signalling Journal website
Publication date:
2015-10-05
DOI:
ISSN:
0898-6568
URN:
uuid:68e5fbbc-14a2-4df2-91e1-04f5d5a2270e
Source identifiers:
574959
Local pid:
pubs:574959

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