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A technique for microsecond heating and cooling of a thin (submicron) biological sample.

Abstract:

Temperature excursions of short duration are useful in exploring the effects of stress on biological systems. Stress will affect the conformation of biological molecules such as proteins, which will lead to an effect on their function. The feasibility of generating such temperature excursions is demonstrated by solving the heat diffusion equation for an aqueous layer on a silicon wafer. The silicon is rapidly heated by a laser pulse and also acts as a heat sink to quench the temperature rise....

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Publisher copy:
10.1007/s00249-002-0228-0

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
Journal:
European biophysics journal : EBJ
Volume:
31
Issue:
5
Pages:
378-382
Publication date:
2002-09-01
DOI:
EISSN:
1432-1017
ISSN:
0175-7571
Source identifiers:
162315

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