Chemical synthesis of the novel Ca2+ messenger NAADP.

Journal article

The first total chemical synthesis of nicotinamide adenine dinucleotide phosphate (beta-NADP, 2) as a single isomer was achieved. This was subsequently converted into the important second messenger nicotinic acid adenine dinucleotide phosphate (p-NAADP) 1 and the identity of this material confirmed by biological evaluation. This flexible synthetic route offers new opportunities for the generation of NAADP 1 analogues that cannot be generated directly from NADP 2 or mainly enzymatic methods.

Authors: Dowden, J; Brown, R; Moreau, C; Galione, A; Potter, B

• Publication status: Published
• Journal: Nucleosides, nucleotides and nucleic acids
• Volume: 24
• Issue: 5-7
• Pages: 513-518
• Publication date: 2005-01-01
• DOI: 10.1081/ncn-200061786
• EISSN: 1532-2335
• ISSN: 1525-7770
• Language: English
• Keywords: Aplysia; Temperature; Calcium Signaling; Magnetic Resonance Spectroscopy; Models, Chemical; Second Messenger Systems; Calcium; Chemistry, Pharmaceutical; NADP; Animals