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Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.

Abstract:

Genome-wide association studies (GWAS) of birth weight have focused on fetal genetics, while relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86,577 women of European descent from the Early Growth Genetics (EGG) Consortium and the UK Biobank. We used structur...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hmg/ddx429

Authors


More from this funder
Name:
Medical Research Council
Grant:
MR/M005070/1
More from this funder
Name:
Seventh Framework Programme
Grant:
669545
More from this funder
Name:
National Institute of Health
Grant:
R01AG29451
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Name:
Royal Society
Grant:
WT104150
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Name:
Wellcome Trust
Grant:
WT097835MF
Publisher:
Oxford University Press
Journal:
Human Molecular Genetics More from this journal
Publication date:
2018-01-01
Acceptance date:
2017-12-15
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Pmid:
29309628
Language:
English
Keywords:
Pubs id:
pubs:817270
UUID:
uuid:68d9eff3-b31f-4ea3-ab5e-c43326dd8144
Local pid:
pubs:817270
Source identifiers:
817270
Deposit date:
2018-01-23

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