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Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.

Abstract:

Genome-wide association studies (GWAS) of birth weight have focused on fetal genetics, while relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86,577 women of European descent from the Early Growth Genetics (EGG) Consortium and the UK Biobank. We used structur...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/hmg/ddx429

Authors


Beaumont, RN More by this author
Warrington, NM More by this author
Cavadino, A More by this author
Tyrrell, J More by this author
Nodzenski, M More by this author
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European Regional Development Fund More from this funder
European Social Fund More from this funder
University of Bergen More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Publication date:
2018-01-05
Acceptance date:
2017-12-15
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Pubs id:
pubs:817270
URN:
uri:68d9eff3-b31f-4ea3-ab5e-c43326dd8144
UUID:
uuid:68d9eff3-b31f-4ea3-ab5e-c43326dd8144
Local pid:
pubs:817270

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