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Velocity of the creatine kinase reaction decreases in postischemic myocardium: a 31P-NMR magnetization transfer study of the isolated ferret heart.

Abstract:

Recovery of postischemic function may be limited by energy synthesis by mitochondria, energy transfer via the creatine kinase reaction, or energy utilization at myofibrils. To identify the limiting step, we defined the relations among oxygen consumption, creatine kinase reaction velocity and cardiac performance in myocardium reperfused following mild, moderate, and severe ischemia. Isolated isovolumic ferret hearts were perfused with Krebs-Henseleit buffer at 37 degrees C. After 30 minutes of...

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Publisher copy:
10.1161/01.res.63.1.1

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Circulation research More from this journal
Volume:
63
Issue:
1
Pages:
1-15
Publication date:
1988-07-01
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Language:
English
Keywords:
Pubs id:
pubs:441444
UUID:
uuid:68d927da-679f-421d-b13a-9f417544ecd3
Local pid:
pubs:441444
Source identifiers:
441444
Deposit date:
2014-02-08

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