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Journal article

Interferon-driven alterations of the host’s amino acid metabolism in the pathogenesis of typhoid fever

Abstract:

Enteric fever, caused by Salmonella enterica serovar Typhi, is an important public health problem in resource-limited settings and, despite decades of research, human responses to the infection are poorly understood. In 41 healthy adults experimentally infected with wild-type S. Typhi, we detected significant cytokine responses within 12 h of bacterial ingestion. These early responses did not correlate with subsequent clinical disease outcomes and likely indicate initial host–pathogen interac...

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Publication status:
Accepted
Peer review status:
Peer reviewed

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Publisher copy:
10.1084/jem.20151025

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More from this funder
Name:
National Institute for Health Research Oxford Biomedical Research Centre
Funding agency for:
Darton, T
Grant:
Clinical Research Fellowship
ClinicalResearchFellowshipstoC.S.Waddington
T.C.Darton
More from this funder
Name:
European Molecular Biology Organization
Funding agency for:
Blohmke, C
Grant:
STF
STF to C.J. Blohmke
More from this funder
Name:
European Union
Funding agency for:
Blohmke, C
Grant:
STF
More from this funder
Name:
National Institutes of Health
Grant:
grant numbersR01AI-036525,U-19AI-082655,
O.RamiloweresupportedinpartbyU-19AI089987,U-19AI057234,
U01AI82210
U19-AI109776toM.B.Sztein
A.Mejias
More from this funder
Name:
Medical Research Council
Grant:
MR/M02637X/1
Publisher:
Rockefeller University Press
Journal:
Journal of Experimental Medicine More from this journal
Volume:
213
Issue:
6
Pages:
1061-1077
Publication date:
2016-01-01
Acceptance date:
2016-04-08
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Pubs id:
pubs:620103
UUID:
uuid:68d6eb45-99dd-45c2-babd-8f38376110f7
Local pid:
pubs:620103
Source identifiers:
620103
Deposit date:
2016-05-12

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