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Journal article

Interferon-driven alterations of the host’s amino acid metabolism in the pathogenesis of typhoid fever

Abstract:

Enteric fever, caused by Salmonella enterica serovar Typhi, is an important public health problem in resource-limited settings and, despite decades of research, human responses to the infection are poorly understood. In 41 healthy adults experimentally infected with wild-type S. Typhi, we detected significant cytokine responses within 12 h of bacterial ingestion. These early responses did not correlate with subsequent clinical disease outcomes and likely indicate initial host–pathogen interac...

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Publication status:
Accepted
Peer review status:
Peer reviewed

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Publisher copy:
10.1084/jem.20151025

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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Funding agency for:
Blohmke, C
Grant:
STF
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Funding agency for:
Blohmke, C
Grant:
STF
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Funding agency for:
Darton, T
Grant:
Clinical Research Fellowship
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Grant:
Strategic Translational Award (grant number 092661
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Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Experimental Medicine Journal website
Volume:
213
Issue:
6
Pages:
1061-1077
Publication date:
2016-01-01
Acceptance date:
2016-04-08
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
620103
Pubs id:
pubs:620103
UUID:
uuid:68d6eb45-99dd-45c2-babd-8f38376110f7
Local pid:
pubs:620103
Deposit date:
2016-05-12

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