Journal article
Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
- Abstract:
-
Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and regulates Met1- and Lys63-linked polyubiquitin and receptor signaling outcomes. Here, we investigate the molecular determinants of CYLD activity. We reveal that two CAP-Gly domains in CYLD are ubiquitin-binding domains and demonstrate a requirement of CAP-...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 37
- Issue:
- 1
- Article number:
- 109777
- Publication date:
- 2021-10-05
- Acceptance date:
- 2021-09-09
- DOI:
- ISSN:
-
2211-1247
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1194023
- Local pid:
- pubs:1194023
- Deposit date:
- 2021-09-10
Terms of use
- Copyright holder:
- Elliott et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Author(s). This is an open access article under a Creative Commons license.
- Licence:
- CC Attribution (CC BY)
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