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Thesis

Using pharmacological and proteomic analysis to investigate molecular pathways in cellular senescence

Abstract:

Upon detection of genotoxic or other stress, cells can withdraw from the cell cycle and become senescent, a fate characterized by resistance to apoptosis, organelle dysfunction and pro-inflammatory secretion. Compelling evidence has highlighted a causal role for senescence in driving pathological ageing, alongside dysregulation of molecular pathways including mTOR and sirtuin signalling. In this thesis, I firstly report generation of a novel model of senescence based on acute treatment of ...

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Division:
MSD
Department:
Biochemistry
Role:
Author

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Role:
Supervisor
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Name:
Oxford Graduate Scholarship in Cell Senescence
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:68d459fd-1972-46ba-9c7b-ded4722e913d
Deposit date:
2019-11-14

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