Journal article
Inclusion of PF68 surfactant improves stability of rAAV titer when passed through a surgical device used in retinal gene therapy
- Abstract:
-
Recent advances in recombinant adeno-associated virus (rAAV) gene therapy for choroideremia show gene replacement to be a promising approach. It is, however, well known that contact of vector solution with plastic materials in the surgical device may result in non-specific adsorption with resulting loss of physical titer and/or level of protein expression and activity. Here we assessed the biocompatibility and stability of rAAV2-REP1 (Rab Escort Protein-1) before and following passage through...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Molecular Therapy - Methods and Clinical Development Journal website
- Volume:
- 17
- Pages:
- 99-106
- Publication date:
- 2019-11-20
- Acceptance date:
- 2019-11-04
- DOI:
- ISSN:
-
2329-0501
- Pmid:
-
31890744
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1080249
- UUID:
-
uuid:68d2ec3a-7659-49e5-8ece-743e4aa36dd9
- Local pid:
- pubs:1080249
- Source identifiers:
-
1080249
- Deposit date:
- 2020-01-15
Terms of use
- Copyright holder:
- Patrício et al
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors. This is an open access article under the CC BY-NC-ND license
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