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Frequent capsule switching in 'ultra-virulent' meningococci - are we ready for a serogroup B ST-11 complex outbreak?

Abstract:

The meningococcal ST-11 complex (cc11) causes large invasive disease outbreaks with high case fatality rates, such as serogroup C (MenC) epidemics in industrialised nations in the 1990s and the serogroup W epidemic currently expanding globally. Glycoconjugate vaccines are available for serogroups A, C, W and Y. Broad coverage protein-based vaccines have recently been licensed against serogroup B meningococci (MenB), however, these do not afford universal MenB protection. Capsular switching fr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jinf.2017.05.015

Authors


Lucidarme, J More by this author
Lekshmi, A More by this author
Parikh, SR More by this author
More by this author
Department:
Oxford, MPLS, Zoology
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Department:
Oxford, MPLS, Zoology
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Funding agency for:
Maiden, M
Meningitis Research Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of Infection Journal website
Volume:
75
Issue:
2
Pages:
95-103
Publication date:
2017-06-01
Acceptance date:
2017-05-27
DOI:
EISSN:
1532-2742
ISSN:
0163-4453
Pubs id:
pubs:698716
URN:
uri:68c43a7d-5d45-4aed-88d3-aade4081e809
UUID:
uuid:68c43a7d-5d45-4aed-88d3-aade4081e809
Local pid:
pubs:698716

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