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NEOSCOPE: a randomised Phase II study of induction chemotherapy followed by either oxaliplatin/capecitabine or paclitaxel/carboplatin based chemoradiation as pre-operative regimen for resectable oesophageal adenocarcinoma.

Abstract:

BACKGROUND: Both oxaliplatin/capecitabine-based chemoradiation (OXCAP-RT) and carboplatin-paclitaxel based radiation (CarPac-RT) are active regimens in oesophageal adenocarcinoma, but no randomised study has compared their efficacy and toxicity. This randomised phase II "pick a winner" trial will identify the optimum regimen to take forward to a future phase III trial against neo-adjuvant chemotherapy, the current standard in the UK. METHODS/DESIGN: Patients with resectable adenocarcinoma of ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12885-015-1062-y

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Publisher:
BioMed Central Publisher's website
Journal:
BMC cancer Journal website
Volume:
15
Issue:
1
Pages:
1062
Chapter number:
ARTN 48
Publication date:
2015-12-05
DOI:
EISSN:
1471-2407
ISSN:
1471-2407
URN:
uuid:68bd0c47-13aa-41a0-8cc0-56581a667247
Source identifiers:
510248
Local pid:
pubs:510248

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