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Journal article

Molecular architecture of the cleavage-dependent mannose patch on a soluble HIV-1 envelope glycoprotein trimer

Abstract:

The formation of a correctly folded and natively glycosylated HIV-1 viral spike is dependent on protease cleavage of the gp160 precursor protein in the Golgi apparatus. Cleavage induces a compact structure, which not only renders the spike capable of fusion but also limits further maturation of its extensive glycosylation. The redirection of the glycosylation pathway to preserve underprocessed oligomannose-type glycans isan important feature in immunogen design as gly...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/JVI.01894-16

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Funding agency for:
Crispin, M
Grant:
1UM1AI100663
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Funding agency for:
Zitzmann, N
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Funding agency for:
Behrens, A
Grant:
Chris Scanlan Memorial Scholarship
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Funding agency for:
Kumar, A
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Publisher:
American Society of Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
91
Issue:
2
Pages:
e01894-16
Publication date:
2016-11-01
Acceptance date:
2016-10-25
DOI:
ISSN:
1098-5514
Source identifiers:
656073
Pubs id:
pubs:656073
UUID:
uuid:68b24854-c438-4b45-9afd-388eed9f78f0
Local pid:
pubs:656073
Deposit date:
2016-11-01

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