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Probing the heme-binding site of the cytochrome c maturation protein CcmE.

Abstract:

Maturation of c-type cytochromes in many bacterial species and plant mitochondria requires the participation of the heme chaperone CcmE that binds heme covalently via a His residue (H130 in Escherichia coli) before transferring it stereospecifically to the apo form of cytochromes c. Only the structure of the apo form of CcmE is known; the heme-binding site has been modeled on the surface of the protein in the vicinity of H130. We have determined the reduction potential of CcmE, which suggests...

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Publication status:
Published

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Publisher copy:
10.1021/bi801609a

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Biochemistry
Volume:
48
Issue:
8
Pages:
1820-1828
Publication date:
2009-03-01
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
Source identifiers:
100025

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