Journal article icon

Journal article

Distinct peptide loading pathways for MHC class II molecules associated with alternative Ii chain isoforms.

Abstract:

Mutant mouse strains expressing either p31 or p41 Ii chain appear equally competent with respect to their class II functional activities including Ag presentation and CD4+ T cell development. To further explore possibly divergent roles provided by alternative Ii chain isoforms, we compare class II structure and function in double mutants also carrying a null allele at the H2-DM locus. As for DM mutants expressing wild-type Ii chain, Aalpha(b)Abeta(b) dimers present in DM-deficient mice expres...

Expand abstract
Publication status:
Published

Actions


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of Immunology
Volume:
160
Issue:
7
Pages:
3101-3110
Publication date:
1998-04-01
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
17150

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP