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Distinct peptide loading pathways for MHC class II molecules associated with alternative Ii chain isoforms.

Abstract:

Mutant mouse strains expressing either p31 or p41 Ii chain appear equally competent with respect to their class II functional activities including Ag presentation and CD4+ T cell development. To further explore possibly divergent roles provided by alternative Ii chain isoforms, we compare class II structure and function in double mutants also carrying a null allele at the H2-DM locus. As for DM mutants expressing wild-type Ii chain, Aalpha(b)Abeta(b) dimers present in DM-deficient mice expres...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
160
Issue:
7
Pages:
3101-3110
Publication date:
1998-04-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:68aaf050-4e84-4a1e-987d-c7c132c4d729
Source identifiers:
17150
Local pid:
pubs:17150

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