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The Ndc80 complex targets Bod1 to human mitotic kinetochores

Abstract:

Regulation of protein phosphatase activity by endogenous protein inhibitors is an important mechanism to control protein phosphorylation in cells. We recently identified Biorientation defective 1 (Bod1) as a small protein inhibitor of protein phosphatase 2A containing the B56 regulatory subunit (PP2A-B56). This phosphatase controls the amount of phosphorylation of several kinetochore proteins and thus the establishment of load-bearing chromosome-spindle attachments in time for accurate separa...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1098/rsob.170099

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
ORCID:
0000-0002-8819-7287
ten Have, S More by this author
Sundaramoorthy, R More by this author
Porter, IM More by this author
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Grant:
097945/B/11/Z; 095931/Z/11/Z
Publisher:
Royal Society Publisher's website
Journal:
Open Biology Journal website
Volume:
7
Issue:
11
Pages:
170099
Publication date:
2017-11-15
Acceptance date:
2017-10-16
DOI:
EISSN:
2046-2441
Pubs id:
pubs:811415
URN:
uri:68a746bb-d3d0-4f04-ae2c-3d48254ca650
UUID:
uuid:68a746bb-d3d0-4f04-ae2c-3d48254ca650
Local pid:
pubs:811415

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