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Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat

Abstract:

Hypertension is associated with heightened cardiac sympathetic drive whilst statins reduce angiotensin II (ATII) signalling, superoxide anion production and increase nitric oxide bioavailability, events that can potentially reduce peripheral cardiac sympathetic neurotransmission. We therefore investigated whether pravastatin alters peripheral cardiac sympathetic control in the spontaneously hypertensive rat (SHR). SHRs (16–18 weeks) had significantly (p < 0.05) enhanced atrial 3H-norepinephri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.yjmcc.2010.09.025

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Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Publisher:
Elsevier
Journal:
Journal of Molecular and Cellular Cardiology More from this journal
Volume:
50
Issue:
1
Pages:
99-106
Publication date:
2010-10-08
Acceptance date:
2010-09-29
DOI:
ISSN:
0022-2828
Language:
English
Keywords:
Pubs id:
pubs:112647
UUID:
uuid:68a67c58-52d0-4a57-b161-ba4b9468f128
Local pid:
pubs:112647
Source identifiers:
112647
Deposit date:
2012-12-19

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