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Identification of differentially expressed genes in experimental models of the tumor microenvironment using differential display.

Abstract:

BACKGROUND: Genes upregulated within the tumour microenvironment represent potential targets for rational drug design. Most studies to date concentrate on the effects of hypoxia, although it is likely many genes are regulated by a more physiological combination of factors. MATERIALS and METHODS: Cells under conditions analogous to the normal and tumour microenvironments were isolated from the plateau-phase system and multicellular spheroids. Gene expression was analysed by differential displa...

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Publication status:
Published

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Authors


Knowles, HJ More by this author
Phillips, RM More by this author
Journal:
Anticancer research
Volume:
21
Issue:
4A
Pages:
2305-2311
Publication date:
2001
EISSN:
1791-7530
ISSN:
0250-7005
URN:
uuid:689ed1e5-4c53-4c8d-a965-0d2bc293d06e
Source identifiers:
109358
Local pid:
pubs:109358

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