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Intracellular antibodies as specific reagents for functional ablation: future therapeutic molecules.

Abstract:

The use of antibodies in medicine and research depends on their specificity and affinity in the recogniton and binding of individual molecules. However, these applications are limited to the extracellular targets. Advances in antibody engineering has allowed the manipulation of the antibody segments containing the antigen-binding regions and generation of small fragments that can be stably expressed in cells. These entities are called intracellular antibodies or intrabodies and have being suc...

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Publisher copy:
10.2174/1566524043360384

Authors


Lobato, MN More by this author
Rabbitts, TH More by this author
Journal:
Current molecular medicine
Volume:
4
Issue:
5
Pages:
519-528
Publication date:
2004-08-05
DOI:
EISSN:
1875-5666
ISSN:
1566-5240
URN:
uuid:689bfb40-d45f-4135-99aa-13653d6cc548
Source identifiers:
324273
Local pid:
pubs:324273

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