Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling.

Journal article

The CD200 receptor (CD200R) negatively regulates myeloid cells by interacting with its widely expressed ligand CD200. CD200R signals through a unique inhibitory pathway involving a direct interaction with the adaptor protein downstream of tyrosine kinase 2 (Dok2) and the subsequent recruitment and activation of Ras GTPase-activating protein (RasGAP). Ligand engagement of CD200R also results in tyrosine phosphorylation of Dok1, but this protein is not essential for inhibitory CD200R signaling ...

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Authors: Mihrshahi, R; Brown, M

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 185
• Issue: 12
• Pages: 7216-7222
• Publication date: 2010-12-01
• DOI: 10.4049/jimmunol.1002858
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Adaptor Proteins, Signal Transducing; Phosphorylation; Oncogene Proteins; Antigens, CD; U937 Cells; Phosphoproteins; Humans; ras GTPase-Activating Proteins; Receptors, Cell Surface; Antigens, Surface; Signal Transduction; Models, Immunological; RNA-Binding Proteins; Myeloid Cells; Protein Binding; DNA-Binding Proteins; Nuclear Proteins