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Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes.

Abstract:

Many aspects of physiology and behavior follow a circadian rhythm. Brain and muscle Arnt-like protein-1 (BMAL1) is a key component of the mammalian molecular clock, which controls circadian oscillations. In the rat, the gene encoding Bmal1 is located within hypertension susceptibility loci. We analyzed the SNP distribution pattern in a congenic interval associated with hypertension in the spontaneously hypertensive rat (SHR), and we show that Bmal1 maps close to a region genetically divergent...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0703247104

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
104
Issue:
36
Pages:
14412-14417
Publication date:
2007-09-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424

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