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Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repair.

Abstract:

Cytokine release at the cartilage/pannus junction (CPJ) may be involved in cartilage destruction and tissue repair in rheumatoid arthritis (RA). Tissue samples of CPJ from 12 RA patients were examined for the presence of cytokines using immunohistochemical techniques with immunoaffinity purified F(ab')2 antibodies raised against recombinant human cytokines. Twenty-four areas of distinct CPJ at which a discrete junction between cartilage and overlying pannus exists were observed. In all specim...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
British journal of rheumatology More from this journal
Volume:
31
Issue:
10
Pages:
653-661
Publication date:
1992-10-01
ISSN:
0263-7103
Language:
English
Keywords:
Pubs id:
pubs:481717
UUID:
uuid:68901692-6048-46af-8fbd-1763bcdcc828
Local pid:
pubs:481717
Source identifiers:
481717
Deposit date:
2014-08-30

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