Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repair.

Journal article

Cytokine release at the cartilage/pannus junction (CPJ) may be involved in cartilage destruction and tissue repair in rheumatoid arthritis (RA). Tissue samples of CPJ from 12 RA patients were examined for the presence of cytokines using immunohistochemical techniques with immunoaffinity purified F(ab')2 antibodies raised against recombinant human cytokines. Twenty-four areas of distinct CPJ at which a discrete junction between cartilage and overlying pannus exists were observed. In all specim...

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Authors: Chu, C; Field, M; Allard, S; Abney, E; Feldmann, M

• Publication status: Published
• Journal: British journal of rheumatology
• Volume: 31
• Issue: 10
• Pages: 653-661
• Publication date: 1992-10-01
• ISSN: 0263-7103
• Language: English
• Keywords: Cartilage, Articular; Arthritis, Rheumatoid; Macrophages; Adult; Immunohistochemistry; Cytokines; Synovial Membrane; Aged; Transforming Growth Factor beta; Middle Aged; Female; Monocytes; Humans; Male