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The effect of changing somatostatin tone on the pituitary growth hormone and thyroid-stimulating hormone responses to their respective releasing factor stimuli.

Abstract:

Somatostatin (SS) inhibits GH and TSH secretion, but its role in modulating their pulsatility is unclear. We studied GH and TSH responses to GH-releasing hormone (GHRH) and TRH stimulation upon a variable background infusion of saline, SS-(1-14) at 20 and 100 micrograms/m2.h, and oral pyridostigmine (30 and 60 mg) in six adult males. Basal GH levels were unaffected by SS-(1-14). Deconvolution analysis of serum GH values demonstrated that the pituitary responded to two GHRH stimuli 90 min apar...

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Publication status:
Published

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Publisher copy:
10.1210/jc.75.2.453

Authors


Spoudeas, HA More by this author
Matthews, DR More by this author
Hindmarsh, PC More by this author
Journal:
The Journal of clinical endocrinology and metabolism
Volume:
75
Issue:
2
Pages:
453-458
Publication date:
1992-08-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:688f6da9-987f-4598-96f9-a857e0f788bb
Source identifiers:
72720
Local pid:
pubs:72720

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