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Journal article : Review

Mechanisms of signalling-memory governing progression through the eukaryotic cell cycle

Abstract:

As cells pass through each replication–division cycle, they must be able to postpone further progression if they detect any threats to genome integrity, such as DNA damage or misaligned chromosomes. Once a ‘decision’ is made to proceed, the cell unequivocally enters into a qualitatively different biochemical state, which makes the transitions from one cell cycle phase to the next switch-like and irreversible. Each transition is governed by a unique signalling network; nonetheless, they share ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ceb.2020.12.003

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Name:
Biotechnology & Biological Sciences Research Council
Grant:
BB/M00354X/1
Publisher:
Elsevier
Journal:
Current Opinion in Cell Biology More from this journal
Volume:
69
Pages:
7-16
Publication date:
2021-01-04
Acceptance date:
2020-12-08
DOI:
EISSN:
1879-0410
ISSN:
0955-0674
Pmid:
33412443
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1158913
Local pid:
pubs:1158913
Deposit date:
2021-01-27

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