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Replacement of asparagine with arginine at the extracellular end of the second transmembrane (M2) region of insect GABA receptors increases sensitivity to penicillin G.

Abstract:

The actions of penicillin-G (PCG) on wild-type and mutant Drosophila GABA receptor (RDL) subunits expressed in Xenopus oocytes were studied under two-electrode voltage-clamp. PCG was found to be a non-competitive antagonist of homomeric Drosophila RDL receptors with an IC(50) of 20.41 +/- 1.66 mM at EC(50) GABA. Substitution of a single amino acid (N318R) at the extracellular end of the channel lining region of the RDL subunit increased the potency of GABA approximately four fold, and increas...

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Publisher copy:
10.1007/s10158-006-0020-4
Journal:
Invertebrate neuroscience : IN More from this journal
Volume:
6
Issue:
2
Pages:
75-79
Publication date:
2006-06-01
DOI:
EISSN:
1439-1104
ISSN:
1354-2516
Language:
English
Keywords:
Pubs id:
pubs:284653
UUID:
uuid:68894a65-c4d5-40c5-95ad-fa7cd850056e
Local pid:
pubs:284653
Source identifiers:
284653
Deposit date:
2013-11-17

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