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Impaired skeletal muscle microvascular function and increased skeletal muscle oxygen consumption in severe falciparum malaria.

Abstract:

BACKGROUND: Organ dysfunction and tissue hypoxia in severe falciparum malaria result from an imbalance between oxygen delivery and demand. In severe malaria, microvascular obstruction from parasite sequestration decreases oxygen delivery. However, host microvascular function (defined as the capacity to increase oxygen delivery in response to ischemia) and oxygen consumption have not been assessed. METHODS: We used near-infrared resonance spectroscopy to measure thenar muscle microvascular fun...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jis692

Authors


Lampah, DA More by this author
Kenangalem, E More by this author
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Journal:
The Journal of infectious diseases
Volume:
207
Issue:
3
Pages:
528-536
Publication date:
2013-02-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:6887ba13-9316-4a50-9900-d49fdc39d115
Source identifiers:
363807
Local pid:
pubs:363807

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