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Breast cancer dormancy can be maintained by small numbers of micrometastases.

Abstract:

Late relapse of breast cancer can occur more than 25 years after primary diagnosis. During the intervening years between initial treatment and relapse, occult cancers are maintained in an apparent state of dormancy that is poorly understood. In this study, we applied a probabilistic mathematical model to long-term follow-up studies of postresection patients to investigate the factors involved in mediating breast cancer dormancy. Our results suggest that long-term dormancy is maintained most o...

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Authors


Alarcón, T More by this author
Wright, NA More by this author
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Journal:
Cancer research
Volume:
70
Issue:
11
Pages:
4310-4317
Publication date:
2010-06-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:6885e084-d779-44b2-994f-c38a5d071bcf
Source identifiers:
72290
Local pid:
pubs:72290

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