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Therapeutic strategies targeting endothelial function in humans: clinical implications.

Abstract:

Persistent oxidative stress in the vascular wall may lead to endothelial dysfunction, a pathological process widely implicated in the morbidities observed in a spectrum of cardiovascular disease. The production of reactive oxygen species (ROS) is regulated by various oxidase enzymes and mitochondrial electron transport mechanisms. Nitric oxide (NO) is a key mediator of endothelial function via its effect on endothelium dependent vascular relaxation. Therapeutic interventions aimed to increase...

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Publication status:
Published

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Publisher copy:
10.2174/157016112798829751

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Antoniades, C More by this author
Journal:
Current vascular pharmacology
Volume:
10
Issue:
1
Pages:
77-93
Publication date:
2012-01-05
DOI:
EISSN:
1875-6212
ISSN:
1570-1611
URN:
uuid:6880fa30-10bd-4b02-b7c7-cb04afca5906
Source identifiers:
206041
Local pid:
pubs:206041

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