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Journal article

Therapeutic strategies targeting endothelial function in humans: clinical implications.

Abstract:

Persistent oxidative stress in the vascular wall may lead to endothelial dysfunction, a pathological process widely implicated in the morbidities observed in a spectrum of cardiovascular disease. The production of reactive oxygen species (ROS) is regulated by various oxidase enzymes and mitochondrial electron transport mechanisms. Nitric oxide (NO) is a key mediator of endothelial function via its effect on endothelium dependent vascular relaxation. Therapeutic interventions aimed to increase...

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Publication status:
Published

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Publisher copy:
10.2174/157016112798829751

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Current vascular pharmacology
Volume:
10
Issue:
1
Pages:
77-93
Publication date:
2012-01-01
DOI:
EISSN:
1875-6212
ISSN:
1570-1611
Source identifiers:
206041
Language:
English
Keywords:
Pubs id:
pubs:206041
UUID:
uuid:6880fa30-10bd-4b02-b7c7-cb04afca5906
Local pid:
pubs:206041
Deposit date:
2012-12-19

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