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Journal article

Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles

Abstract:: Trans-acting genetic variants have a substantial, albeit poorly characterized, role in the heritable determination of gene expression. Using paired purified primary monocytes and B cells, we identify new predominantly cell type-specific cis and trans expression quantitative trait loci (eQTLs), including multi-locus trans associations to LYZ and KLF4 in monocytes and B cells, respectively. Additionally, we observe a B cell-specific trans association of rs11171739 at 12q13.2, a known autoimmune...
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APA Style

Fairfax, B., Makino, S., Radhakrishnan, J., Plant, K., Leslie, S., Dilthey, A., Ellis, P., Langford, C., Vannberg, F., & Knight, J. (2012). Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nature Genetics, 44(5), 502–510.

MLA Style

Fairfax, B., et al. “Genetics of Gene Expression in Primary Immune Cells Identifies Cell Type-Specific Master Regulators and Roles of HLA Alleles.” Nature Genetics, vol. 44, no. 5, 2012, pp. 502–10.

Chicago Style

Fairfax, B, S Makino, J Radhakrishnan, K Plant, S Leslie, A Dilthey, P Ellis, C Langford, F Vannberg, and J Knight. 2012. “Genetics of Gene Expression in Primary Immune Cells Identifies Cell Type-Specific Master Regulators and Roles of HLA Alleles.” Nature Genetics 44 (5): 502–10.
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Publisher copy:: 10.1038/ng.2205

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+ Fairfax, B More by this author

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+ Makino, S More by this author

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+ Radhakrishnan, J More by this author

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+ Plant, K More by this author

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+ Leslie, S More by this author

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Bibliographic Details

Journal:: Nature Genetics
Volume:: 44
Issue:: 5
Pages:: 502-510
Publication date:: 2012-05-01
DOI:: 10.1038/ng.2205
EISSN:: 1546-1718
ISSN:: 1061-4036

Item Description

Language:: English
Pubs id:: pubs:329391
UUID:: uuid:687627ef-b0fa-46a6-bd9f-4a17e7a849c6
Local pid:: pubs:329391
Source identifiers:: 329391
Deposit date:: 2012-12-19

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Copyright date:: 2012

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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