Journal article
Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.
- Abstract:
-
The T-cell receptor (TCR) consists of a TCRαβ heterodimer, a TCRζ homodimer, and CD3γε and CD3δε heterodimers. The precise mechanism of T-cell triggering following TCR ligand engagement remains elusive. Previous studies reported that the cytoplasmic tail of CD3ε binds to the plasma membrane through a basic residue-rich stretch (BRS) and proposed that dissociation from the membrane is required for phosphorylation thereof. In this report we show that BRS motifs within the cytoplasmic tail of TC...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.1108052108
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Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 108
- Issue:
- 48
- Pages:
- 19323-19328
- Publication date:
- 2011-11-01
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
221703
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:221703
- UUID:
-
uuid:686d39e6-0462-4d5d-8370-e1813c6addd4
- Local pid:
- pubs:221703
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2011
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