- Abstract:
-
The T-cell receptor (TCR) consists of a TCRαβ heterodimer, a TCRζ homodimer, and CD3γε and CD3δε heterodimers. The precise mechanism of T-cell triggering following TCR ligand engagement remains elusive. Previous studies reported that the cytoplasmic tail of CD3ε binds to the plasma membrane through a basic residue-rich stretch (BRS) and proposed that dissociation from the membrane is required for phosphorylation thereof. In this report we show that BRS motifs within the cytoplasmic tail of TC...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.1108052108
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 108
- Issue:
- 48
- Pages:
- 19323-19328
- Publication date:
- 2011-11-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:686d39e6-0462-4d5d-8370-e1813c6addd4
- Source identifiers:
-
221703
- Local pid:
- pubs:221703
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.
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