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Journal article

Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.

Abstract:

The T-cell receptor (TCR) consists of a TCRαβ heterodimer, a TCRζ homodimer, and CD3γε and CD3δε heterodimers. The precise mechanism of T-cell triggering following TCR ligand engagement remains elusive. Previous studies reported that the cytoplasmic tail of CD3ε binds to the plasma membrane through a basic residue-rich stretch (BRS) and proposed that dissociation from the membrane is required for phosphorylation thereof. In this report we show that BRS motifs within the cytoplasmic tail of TC...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1108052108

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
108
Issue:
48
Pages:
19323-19328
Publication date:
2011-11-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:686d39e6-0462-4d5d-8370-e1813c6addd4
Source identifiers:
221703
Local pid:
pubs:221703

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