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Atypical phenotypes from flatworm Kv3 channels.

Abstract:

Divergence of the Shaker superfamily of voltage-gated (Kv) ion channels early in metazoan evolution created numerous electrical phenotypes that were presumably selected to produce a wide range of excitability characteristics in neurons, myocytes, and other cells. A comparative approach that emphasizes this early radiation provides a comprehensive sampling of sequence space that is necessary to develop generally applicable models of the structure-function relationship in the Kv potassium chann...

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Publisher copy:
10.1152/jn.00858.2005

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Journal:
Journal of neurophysiology
Volume:
95
Issue:
5
Pages:
3035-3046
Publication date:
2006-05-01
DOI:
EISSN:
1522-1598
ISSN:
0022-3077
Source identifiers:
284305

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