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Atypical phenotypes from flatworm Kv3 channels.

Abstract:

Divergence of the Shaker superfamily of voltage-gated (Kv) ion channels early in metazoan evolution created numerous electrical phenotypes that were presumably selected to produce a wide range of excitability characteristics in neurons, myocytes, and other cells. A comparative approach that emphasizes this early radiation provides a comprehensive sampling of sequence space that is necessary to develop generally applicable models of the structure-function relationship in the Kv potassium chann...

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Publisher copy:
10.1152/jn.00858.2005

Authors


Klassen, TL More by this author
Buckingham, SD More by this author
Atherton, DM More by this author
Gallin, WJ More by this author
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Journal:
Journal of neurophysiology
Volume:
95
Issue:
5
Pages:
3035-3046
Publication date:
2006-05-05
DOI:
EISSN:
1522-1598
ISSN:
0022-3077
URN:
uuid:6869e0d7-3f1e-4318-99fd-b30c798560d8
Source identifiers:
284305
Local pid:
pubs:284305

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