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CR1 Knops blood group alleles are not associated with severe malaria in the Gambia.

Abstract:

The Knops blood group antigen erythrocyte polymorphisms have been associated with reduced falciparum malaria-based in vitro rosette formation (putative malaria virulence factor). Having previously identified single-nucleotide polymorphisms (SNPs) in the human complement receptor 1 (CR1/CD35) gene underlying the Knops antithetical antigens Sl1/Sl2 and McC(a)/McC(b), we have now performed genotype comparisons to test associations between these two molecular variants and severe malaria in West A...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gene.6363980

Authors


Zimmerman, PA More by this author
Fitness, J More by this author
Moulds, JM More by this author
McNamara, DT More by this author
Kasehagen, LJ More by this author
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Volume:
4
Issue:
5
Pages:
368-373
Publication date:
2003-07-05
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
URN:
uuid:68678d3e-8282-4987-83e0-81f3cfb05e74
Source identifiers:
53864
Local pid:
pubs:53864

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