- Abstract:
-
HIV cannot be cured by current antiretroviral therapy (ART) because it persists in a transcriptionally silent form in long-lived CD4+ cells. Leading efforts to develop a functional cure have prioritized latency reversal to expose infected cells to immune surveillance, coupled with enhancement of the natural cytolytic function of immune effectors, or “kick and kill.” The most clinically advanced approach to improving the kill is therapeutic immunization, which aims to augment or re-focus HIV-s...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 548.2kb)
-
- Publisher copy:
- 10.3389/fimmu.2018.02861
-
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- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Immunology Journal website
- Volume:
- 9
- Pages:
- Article: 2861
- Publication date:
- 2018-12-04
- Acceptance date:
- 2018-11-20
- DOI:
- ISSN:
-
1664-3224
- Pubs id:
-
pubs:953267
- URN:
-
uri:6865cdfd-8f1c-465d-908a-f8f19ff29539
- UUID:
-
uuid:6865cdfd-8f1c-465d-908a-f8f19ff29539
- Local pid:
- pubs:953267
- Copyright holder:
- Yang et al.
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Yang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Journal article
Therapeutic targeting of HIV reservoirs: how to give T cells a new direction
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