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Therapeutic targeting of HIV reservoirs: how to give T cells a new direction

Abstract:

HIV cannot be cured by current antiretroviral therapy (ART) because it persists in a transcriptionally silent form in long-lived CD4+ cells. Leading efforts to develop a functional cure have prioritized latency reversal to expose infected cells to immune surveillance, coupled with enhancement of the natural cytolytic function of immune effectors, or “kick and kill.” The most clinically advanced approach to improving the kill is therapeutic immunization, which aims to augment or re-focus HIV-s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3389/fimmu.2018.02861

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Article number:
2861
Publication date:
2018-12-04
Acceptance date:
2018-11-20
DOI:
ISSN:
1664-3224
Source identifiers:
953267
Language:
English
Keywords:
Pubs id:
pubs:953267
UUID:
uuid:6865cdfd-8f1c-465d-908a-f8f19ff29539
Local pid:
pubs:953267
Deposit date:
2018-12-31

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