Fluid mechanics of nodal flow due to embryonic primary cilia.

Journal article

Breaking of left-right symmetry is crucial in vertebrate development. The role of cilia-driven flow has been the subject of many recent publications, but the underlying mechanisms remain controversial. At approximately 8 days post-fertilization, after the establishment of the dorsal-ventral and anterior-posterior axes, a depressed structure is found on the ventral side of mouse embryos, termed the ventral node. Within the node, 'whirling' primary cilia, tilted towards the posterior, drive a f...

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Authors: Smith, D; Blake, JR; Gaffney, E

• Publication status: Published
• Journal: Journal of the Royal Society, Interface / the Royal Society
• Volume: 5
• Issue: 22
• Pages: 567-573
• Publication date: 2008-05-01
• DOI: 10.1098/rsif.2007.1306
• EISSN: 1742-5662
• ISSN: 1742-5689
• Language: English
• Keywords: Biomechanical Phenomena; Models, Biological; Embryo, Mammalian; Cilia; Animals