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MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis.

Abstract:

BACKGROUND: The role of circulating homocysteine as an atherosclerosis risk factor has recently been questioned. However, 5-methyl-tetrahydrofolate (5-MTHF), the circulating metabolite of folic acid participating in homocysteine metabolism, has direct effects on vascular function. We sought to distinguish the effects of plasma versus vascular tissue 5-MTHF and homocysteine on vascular redox and endothelial nitric oxide bioavailability in human vessels. METHODS AND RESULTS: We used the methyl...

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Publication status:
Published

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Journal:
Circulation More from this journal
Volume:
119
Issue:
18
Pages:
2507-2515
Publication date:
2009-05-01
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Language:
English
Keywords:
Pubs id:
pubs:105153
UUID:
uuid:6857d6ce-d8d1-4e6a-ad23-d347c0e18b3b
Local pid:
pubs:105153
Source identifiers:
105153
Deposit date:
2012-12-19

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