A very stable cyclic DNA miniduplex with just two base pairs.

Journal article

(Chemical Equation Presented) What goes around... Cyclic mini-DNA duplexes, as shown in the scheme, have been synthesized in high yield on the multimicromole scale by using click chemistry. These B-like duplexes are very stable and bind to drugs, such as distamycin A and 7-aminoactinomycin D. Circular dichroism indicates that the bases are stacked, and UV melting and NMR spectroscopy showed that the interbase hydrogen bonds are very stable, even in a dimer. © 2008 Wiley-VCH Verlag GmbH and Co. KGaA.

Authors: El-Sagheer, A; Kumar, R; Findlow, S; Werner, J; Lane, A

• Publication status: Published
• Journal: Chembiochem : a European journal of chemical biology
• Volume: 9
• Issue: 1
• Pages: 50-52
• Publication date: 2008-01-01
• DOI: 10.1002/cbic.200700538
• EISSN: 1439-7633
• ISSN: 1439-4227
• Language: English
• Keywords: Oligonucleotides; Cyclization; Base Sequence; DNA; Cross-Linking Reagents; Base Pairing; Nanotechnology