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Neuregulin 1 type I overexpression is associated with reduced NMDA receptor-mediated synaptic signaling in hippocampal interneurons expressing PV or CCK

Abstract:

Hypofunction of N-methyl-d-aspartate receptors (NMDARs) in inhibitory GABAergic interneurons is implicated in the pathophysiology of schizophrenia (SZ), a heritable disorder with many susceptibility genes. However, it is still unclear how SZ risk genes interfere with NMDAR-mediated synaptic transmission in diverse inhibitory interneuron populations. One putative risk gene is neuregulin 1 (NRG1), which signals via the receptor tyrosine kinase ErbB4, itself a schizophrenia risk gene. The type I...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1523/ENEURO.0418-17.2018

Authors


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Role:
Author
ORCID:
0000-0001-5894-6569
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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Oxford college:
Wolfson College
Role:
Author
ORCID:
0000-0002-6719-1126
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Wellcome Trust More from this funder
Hungarian Academy of Sciences More from this funder
University of Oxford More from this funder
Medical Research Council More from this funder
John Fell Fund More from this funder
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Publisher:
Society for Neuroscience Publisher's website
Journal:
eNeuro Journal website
Volume:
5
Issue:
2
Pages:
e0418-17
Publication date:
2018-04-20
Acceptance date:
2018-02-28
DOI:
EISSN:
2373-2822
Source identifiers:
847107
Language:
English
Keywords:
Pubs id:
pubs:847107
UUID:
uuid:684bd4af-b386-491b-816f-9af901af5b0a
Local pid:
pubs:847107
Deposit date:
2018-06-15

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