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Hyperglycaemic siblings of Type II (non-insulin-dependent) diabetic patients have increased PAI-1, central obesity and insulin resistance compared with their paired normoglycaemic sibling.

Abstract:

AIMS/HYPOTHESIS: First-degree relatives of Type II (non-insulin-dependent) diabetic patients in cross-sectional studies have increased insulin resistance, associated cardiovascular risk factors and abnormalities of fibrinolysis and coagulation. To minimise between-family genetic and environmental confounders, we investigated within-family relationships between early hyperglycaemia and risk factors. METHODS: Thirteen age and gender matched sibling pairs of Type II (non-insulin-dependent) diabe...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-002-0795-8

Authors


Herlihy, OM More by this author
Barrow, BA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Diabetologia
Volume:
45
Issue:
5
Pages:
635-641
Publication date:
2002-05-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:684a6168-cab7-4133-9020-e669e76058cc
Source identifiers:
973
Local pid:
pubs:973

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