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Prevention of early islet graft failure by selective inducible nitric oxide synthase inhibitors after pig to nude rat intraportal islet transplantation.

Abstract:

BACKGROUND: Clinical and experimental data indicate that early failure of intraportally grafted islets is caused by inflammation including secretion of cytokines and nitric oxide. Direct inducible nitric oxide synthase suppression may avoid detrimental effects associated with steroid administration. We compared the efficiency of selective and unselective inducible nitric oxide synthase inhibitors with dexamethasone to suppress nitric oxide generation after intraportal islet xenotransplantatio...

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Zwolinski, A More by this author
Bretzel, RG More by this author
Journal:
Transplantation
Volume:
71
Issue:
2
Pages:
179-184
Publication date:
2001-01-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:684220dc-3430-4841-b61d-0cca10dd554d
Source identifiers:
263932
Local pid:
pubs:263932

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