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Structural Basis for LMO2-Driven Recruitment of the SCL: E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets

Abstract:

Cell fate is governed by combinatorial actions of transcriptional regulators assembling into multiprotein complexes. However, the molecular details of how these complexes form are poorly understood. One such complex, which contains the basic-helix-loop-helix heterodimer SCL:E47 and bridging proteins LMO2:LDB1, critically regulates hematopoiesis and induces Tcell leukemia. Here, we report the crystal structure of (SCL:E47)bHLH:LMO2:LDB1LID bound to DNA, providing a molecular account of the net...

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Authors


ElOmari, K More by this author
Hoosdally, SJ More by this author
Tuladhar, K More by this author
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Journal:
Cell Reports
Volume:
4
Issue:
1
Pages:
135-147
Publication date:
2013-07-11
DOI:
EISSN:
2211-1247
URN:
uuid:6841b191-5689-41c5-a91d-788384f04029
Source identifiers:
448248
Local pid:
pubs:448248

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