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Atrial fibrillation is associated with left ventricular dysfunction and impaired myocardial energetics that persist despite catheter ablation: Is atrial fibrillation the chicken or the egg?

Abstract:

Atrial fibrillation (AF) is associated with increased risk of heart failure and premature death, and is often resistant to treatment. Animal models of pacing-induced AF indicate that AF-induced endothelial dysfunction, impaired coronary reserve, and myocardial remodelling are important in arrhythmia maintenance. However, human AF may reflect a subclinical cardiomyopathy, which persists after sinus rhythm (SR) restoration and provides a substrate for AF recurrence. To test this hypothesis, we ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1136/heartjnl-2016-309890.138

Authors


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Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
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Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Eichhorn, C More by this author
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Department:
Oxford, MSD, Physiology Anatomy & Genetics
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Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
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Publisher:
BMJ Publishing Group Publisher's website
Publication date:
2016-06-05
DOI:
EISSN:
1468-201X
ISSN:
1355-6037
Pubs id:
pubs:715620
URN:
uri:683e9e2d-832f-4c0c-b944-b8b2471b95c2
UUID:
uuid:683e9e2d-832f-4c0c-b944-b8b2471b95c2
Local pid:
pubs:715620

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