Journal article icon

Journal article

Molecular basis of the allosteric mechanism of cAMP in the regulatory PKA subunit.

Abstract:

The second messenger cyclic Adenosine MonoPosphate (cAMP) mediates many biological process by interacting with structurally conserved nucleotide binding domains (cNBD's). Here, we use molecular dynamics simulations on RIIbeta-PKA, one of the best characterized members of the cNBD family, in presence and absence of cAMP. The results of our calculations are fully consistent with the available experimental data and suggest that the key factor of the cAMP allosteric mechanism in cNBDS's is the in...

Expand abstract

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
FEBS letters More from this journal
Volume:
579
Issue:
12
Pages:
2679-2685
Publication date:
2005-05-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP