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Genome organization is a major component of gene expression control in response to stress and during the cell division cycle in trypanosomes

Abstract:

The trypanosome genome is characterized by RNA polymerase II-driven polycistronic transcription of protein-coding genes. Ten to hundreds of genes are co-transcribed from a single promoter; thus, selective regulation of individual genes via initiation is impossible. However, selective responses to external stimuli occur and post-transcriptional mechanisms are thought to account for all temporal gene expression patterns. We show that genes encoding mRNAs that are differentially regulated during...

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P. K. Maini More by this author
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Publication date:
2012-04-04
URN:
uuid:682dc5fb-c330-46d9-9a7e-7f00da66bfee
Local pid:
oai:eprints.maths.ox.ac.uk:1508

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