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Journal article

Downregulation of the T-cell receptor by human immunodeficiency virus type 2 Nef does not protect against disease progression.

Abstract:

Chronic immune activation is thought to play a major role in human immunodeficiency virus (HIV) pathogenesis, but the relative contributions of multiple factors to immune activation are not known. One proposed mechanism to protect against immune activation is the ability of Nef proteins from some HIV and simian immunodeficiency virus strains to downregulate the T-cell receptor (TCR)-CD3 complex of the infected cell, thereby reducing the potential for deleterious activation. HIV type 1 (HIV-1)...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.01252-09

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Journal of virology More from this journal
Volume:
83
Issue:
24
Pages:
12968-12972
Publication date:
2009-12-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:1176
UUID:
uuid:682a2589-b696-43a0-9c8e-42f861a2b4c4
Local pid:
pubs:1176
Source identifiers:
1176
Deposit date:
2012-12-19

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