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Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

Abstract:

While it is well-established that distal hypoxia response elements (HREs) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HREs has not been described so far. Hepatic Epo expression is regulated by a HRE located downstream of the EPO gene, but this 3' HRE is dispensable for renal EPO gene expression. We previously identified a 5' HRE and could show that both HREs direct exogenous reporter gene expre...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Name:
Cancer Research UK
Grant:
16016
More from this funder
Name:
National Institute for Health Research
Grant:
RP-2015-06-004
Publisher:
Ferrata Storti Foundation
Journal:
Haematologica More from this journal
Volume:
105
Issue:
12
Pages:
2774-2784
Publication date:
2019-12-19
Acceptance date:
2019-12-18
DOI:
EISSN:
1592-8721
ISSN:
0390-6078
Pmid:
31857363
Language:
English
Keywords:
Pubs id:
1079685
Local pid:
pubs:1079685
Deposit date:
2020-06-06

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