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Disentangling the genetics of lean mass

Abstract:

Background:Lean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify genetic signals having an association with both lean mass and fat mass. Objectives:To determine the impact of different fat mass adjustments on genetic architecture of LM and identify additional LM loci. Methods:We performed genome-wide association analyses for wh...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/ajcn/nqy272

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Contributors

Department:
Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA.
Publisher:
Oxford University Press Publisher's website
Journal:
American Journal of Clinical Nutrition Journal website
Volume:
109
Issue:
2
Pages:
276-287
Publication date:
2019-02-05
Acceptance date:
2018-09-11
DOI:
EISSN:
1938-3207
ISSN:
0002-9165
Pubs id:
pubs:969098
URN:
uri:6821c6d2-1080-4533-ac13-8b590f5dc4b9
UUID:
uuid:6821c6d2-1080-4533-ac13-8b590f5dc4b9
Local pid:
pubs:969098
Language:
English
Keywords:

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