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Tandem inverse-electron-demand hetero-/retro-Diels-Alder reactions for aromatic nitrogen heterocycle synthesis.

Abstract:

The merged inverse-electron-demand hetero-Diels-Alder (ihDA)/retro-Diels-Alder (rDA) reaction sequence can be used to rapidly synthesise highly functionalised nitrogen heteroaromatics. The reaction offers many advantages: high atom economy, high levels of regioselectivity, it rarely requires a catalyst and, in some cases, can be performed in the absence of solvent. In this tutorial review we discuss the range of commonly used dienophiles and aza-dienes for this process whilst highlighting the...

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Publication status:
Published

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Publisher copy:
10.1039/c2cs35316d

Authors


Foster, RA More by this author
Willis, MC More by this author
Journal:
Chemical Society reviews
Volume:
42
Issue:
1
Pages:
63-76
Publication date:
2013-01-05
DOI:
EISSN:
1460-4744
ISSN:
0306-0012
URN:
uuid:6820fbbd-3063-4227-a39a-96e52e2a2bf2
Source identifiers:
356185
Local pid:
pubs:356185
Language:
English

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