Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content.

Journal article

BACKGROUND: HDL cholesterol levels are inversely correlated with coronary heart disease risk in humans, and in animal studies, HDL elevation decreases formation and progression of foam-cell lesions. The potential for HDL to affect preexisting advanced atherosclerotic lesions is not known. To approach this issue, we used a novel mouse aortic transplantation model. METHODS AND RESULTS: ApoE-deficient (EKO) mice were fed a Western-type diet for 6 months, and thoracic aortic segments containing a...

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Authors: Rong, J; Li, J; Reis, E; Choudhury, R; Dansky, H

• Publication status: Published
• Journal: Circulation
• Volume: 104
• Issue: 20
• Pages: 2447-2452
• Publication date: 2001-11-01
• DOI: 10.1161/hc4501.098952
• EISSN: 1524-4539
• ISSN: 0009-7322
• Language: English
• Keywords: Cholesterol; Animals; Mice, Transgenic; Macrophages; Apolipoproteins E; Arteriosclerosis; Apolipoprotein A-I; Humans; Mice; Aorta; Cholesterol, HDL; Actins; Mice, Knockout; Muscle, Smooth, Vascular